Quinoline derivatives and use thereof as angiotensin II antagoni

Details Quinoline derivatives and use thereof as angiotensin II antagoni Quinoline derivatives and use thereof as angiotensin II antagoni

1993-05-04

1995-08-22

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514290, 546 4, 546 10, 546110, 546153, 546155, 546156, 546157, A61K 3147, C07D215233

Patent

active

054440718

ABSTRACT:
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Ra, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. ##STR1##

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