Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-08-20
2000-11-07
Seaman, D. Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546153, 546154, 514312, 514313, C07D215227, A61K 314704
Patent
active
061438952
ABSTRACT:
The present invention relates to novel tetrahydro-quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and Y have the meanings provided.
REFERENCES:
patent: 4692522 (1987-09-01), Parsons et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5182366 (1993-01-01), Huebner et al.
patent: 5231102 (1993-07-01), Baker et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5324483 (1994-06-01), Cody et al.
Clarke et al., "The conversion of 2-(2-chloroacetamido)benzophenones into 2,3-Dihydro-2-oxo-1,4-benzodiazepines. Part I. With Ammonia." J. Chem. Research, 398 (1980).
Gallop et al., "Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries." J. of Med. Chem., 37(9):1233-1251 (1994).
Gewald et al., "4-Amino-3-pyridiniochinolin-2(1H)-on-chloride und 3,4-Diaminochinolin-2 (1H)-one." Chem. Res., 124:1237-1241 (1991).
Gordon et al., "Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions." J. of Med. Chem., 37(10):1386-1401 (1994).
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery." Nature, 354:94-96 (1991).
Leznoff C., "Use of insoluble polymer supports in organic chemical synthesis," Chem. Soc. Rev. 3:65-85 (1974).
Manhas et al., "beta-Lactams as Synthons. Synthesis of Heterocycles via beta-Lactam Cleavage." Heterocycles, 5:669-699 (1976).
Kano et al., "Formation of some heterocycles through ring transformation of 1-arylazetidin-2-ones." Heterocycles, 8:411-416 (1977).
Ojima and Pei, "Novel rearrangements of chiral 3-oxazolidinylazetidin-2-ones." Tetrahedron Letters, 33(7):887-890 (1992).
Ostresh et al., "Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity." Proc. Natl., Acad. Sci. USA, 9:11138-11142 (1994).
Stadlbauer, Wolfgang, "Methoden zur darstellung von 4-Azido-2 (1H )-chinolonen [1]," Monatshefte fur chemie, 117:1305-1323 (1986).
Kiely John S.
Pei Yazhong
Seaman D. Margaret
Trega Biosciences, Inc.
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