Quinoline derivatives and quinazoline derivatives inhibiting...

Details Quinoline derivatives and quinazoline derivatives inhibiting... Quinoline derivatives and quinazoline derivatives inhibiting...

2003-05-01

2009-10-06

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S312000, C546S157000, C546S163000, C544S287000

Reexamination Certificate

active

07598258

ABSTRACT:
An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof:wherein X represents CH or N; Z represents O or S; R1, R2, and R3represent H, optionally substituted alkoxy or the like; R4represents H; R5, R6, R7, and R8represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9and R10represent H, alkyl or the like; and any one of R11and R12represents H with the other representing alkyl and R13represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11represents H and R12and R13combine together to form a bicyclic carbocyclic ring.

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U.S. Appl. No. 11/526,739, filed Sep. 26, 2006, Kubo et al.

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