Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-02
1997-06-24
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514311, 546153, 546156, 546168, 546180, A61K 3147, C07D21560, C07D21514
Patent
active
056417888
ABSTRACT:
The present invention provides a novel quinoline derivative useful as an anti-inflammatory agent, particularly an agent for treating arthritis, or a salt thereof. The present invention also provides a composition, particularly an anti-inflammatory composition for pharmaceutical use, comprising the novel quinoline compound of formula (I): ##STR1## wherein G is an acyl group, optionally protected hydroxyalkyl group, amidated carboxyl group or halogen atom;
X is an oxygen atom, optionally oxidized sulfur atom or --(CH.sub.2).sub.q -- in which q is an integer of 0 to 5;
R is an optionally substituted amino group or optionally substituted heterocyclic group;
each of the ring A and ring B may optionally be substituted; and
k is 0 or 1.
REFERENCES:
Walser et al., "Nucleophilic Displacement of Aromatic Fluorine. Part IV. Quinolinoquinolines and Benzochromenoquinolines," J. Heterocyclic Chem., vol. 12(4), pp. 737-741, (1975).
Fehnel et al., "Friedlander Syntheses With o-Aminoaryl Ketones. II. Structure of the Product Formed IN the Condensation of o-Aminobenzophenone With Acetylacetone", J.O.C., vol. 31(11), pp. 3852-3854, (1966).
Chemical Abstracts, vol. 79:348, (1973), p. 348.
Partial English Translation of Nippon Kagaku Zasshi, vol. 99(1), pp. 81-85, (1969).
Synthesis International Journal of Methods in Synthetic Organic Chemistry, No. 9, pp. 718-719, (1979).
Anzini et al., "Synthesis And 5HT-Receptors Affinity Of Some 4-Phenylquinoline Derivatives", IL Farmaco, vol. 44(6), pp. 555-563, (1989).
Baba Atsuo
Makino Haruhiko
Sohda Takashi
Ivy C. Warren
M. Mach D. Margaret
Takeda Chemical Industries Ltd.
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