Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1999-07-14

2000-10-17

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142328, 544128, 546155, A61K 314704, C07D21556, A61P 2900, A61P 3700

Patent

active

061332852

ABSTRACT:
The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCH.sub.x F.sub.y, wherein

REFERENCES:
patent: 5726183 (1998-03-01), Nilsson
patent: 5728713 (1998-03-01), Nilsson
King FD. Medicinal Chemistry: Principles and Practice. The Royal Society of Chemistry. pp. 206-208, 1994.
Harrcourt, "Polyarteritis in colony of beagles", The Veterinary Records, pp.519-522, (1978).
Kelly et al., "Polyarteritis in the Dog: A Case Report", The Veterinary Records, pp. 363-366 (1973).
Andersen et al., "Linomide reduced the rate of active lesions in relapsing-remitting multiple sclerosis" Neurology, vol.47, pp.895-900, (1996).
Karussis et al., "Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide" Neurology, vol.47, pp.341-346, (1996).
Bai et al., "Linomide-induced suppression of experimental autoimmune neuritis is associated with down-regulated macrophage function", Journal of Neuroimmunology, vol.76, pp.177-184, (1997).
Karussis et al., "Immunomodulation of experimental autoimmune myasthenia gravis with linomide", Journal of Neuroimmunology, vol.55, pp. 187-193, (1994).
Gross et al., "Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug", Diabetologia, vol.37, pp. 1195-1201, (1994).
Gonzalo et al., "Linomide inhibits programmed cell death of peripheral T cells in vivo", Eur. J. Immunol. vol.24, pp.48-52, (1994).
Karussis et al., "Treatment of chronic-relasping experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide)", Proc. Natl. Acad. Sci., vol.90, pp. 6400-6404, (1993).
Gonzalo et al., "Linomide, a novel immunomodulator that prevents death in four models of septic shock" Eur. J. Immunol., vol.23, pp.2372-2374, (1993).
Kalland, "Regulation of Natural Killer Progenitors", The Journal of Immunology, vol.144, pp.4472-4476, (1990).
Larrson, "Mechanism of Action of the New Immunomodulator LS2616 on T cells Response", Int. J. Immuno., vol.9 No.4, pp.425-431, (1987).
Wanders et al., Abolition of the Effects of Cyclosporine on Rat Cardiac Allograft Rejection by the New Immunomodulator LS-2616 (Linomide), vol.47, pp.216-217, (1989).
Tarkowski et al., "Successful Treatment of Autoimmuniyt in MRL/1 Mice with LS-2616, A new immunomodulator" Arthritis and Rheumatism, vol.29, No.11, pp.1405-1409, (1986).
Prineas, The neuropathyology of multiple sclerosis, Handbook of Clinical Neurology, vol.3, No.47, pp.213-257 (1985).
Talal, "Autoimmune Disease", Autoimmune Disease, pp.195-198.
Japanese Abstract 07252228.
Japanese Abstract 00722404.

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