Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1988-12-16

1990-05-08

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 93, 546101, 546153, 546155, 546174, 546178, 546180, 546181, C07D21504

Patent

active

049239910

ABSTRACT:
The invention provides a compound of formula III ##STR1## or an acid addition salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and represent hydrogen or lower alkyl, cycloalkyl, lower aralkyl or phenyl radicals any of which radicals may be substituted by lower alkyl, lower alkoxy or trifluoromethyl or R.sup.2 and R.sup.3 taken together, form a 5, 6 or 7 membered saturated ring, R.sup.4 and R.sup.5 may also represent lower alkoxy or cycloalkoxy, n is 1, 2 or 3 and, if more than one R.sup.4 radical is present the R.sup.4 radicals may be the same or different and esters of carboxylic acids with the hydroxy group shown, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined above, with the provisos that (1) R.sup.6 and R.sup.7 are other than hydrogen when R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are all hydrogen and (2) R.sup.6 and R.sup.7 are not both methyl when R.sup.4 is methyl.
Compounds III are intermediates for other compounds with anti-ulcer or anti-secretory activity. Some of the compounds III are intermediates for anti-inflammatory agents.

REFERENCES:
patent: 4022792 (1977-05-01), Albertson et al.
patent: 4046895 (1977-09-01), Curran et al.
patent: 4085215 (1978-04-01), Curran et al.
Hahn et al., Roczniki Chemii 38, 989 (1964).
Rosen et al., J. Org. Chem. 42, 47 (1977).

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