Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1984-02-23

1986-03-18

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, A61K 3147, C07D21522

Patent

active

045769532

ABSTRACT:
Compounds of the formula: ##STR1## wherein X stands for an oxygen or sulphur atom, n stands for 1 or 2, R.sup.1 stands for a defined (3-4C)alkyl radical, a cyclopropyl radical, or a phenyl radical which may optionally bear a halogeno, (1-4C)alkyl or (1-4C)alkoxy substituent, and R.sup.2 stands for hydrogen or a (1-4C)alkyl radical, and pharmaceutically-acceptable acid-addition salts thereof. Process for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are peripherally selective 5-HT antagonists.

REFERENCES:
patent: 1572768 (1926-02-01), Callsen
patent: 4435405 (1984-03-01), Blackburn
March, "Advanced Organic Chemistry", 2nd Edition, p. 819.

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