Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1992-09-18

1993-08-31

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514292, 514297, 546 79, 546 93, 546104, 540521, 540580, C07D40104, C07D40106, C07D47104, A61K 3155

Patent

active

052409341

ABSTRACT:
Quinoline derivatives of the formula, ##STR1## wherein >A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior anti-acetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.

REFERENCES:
Journal of Medicinal Chemistry, vol. 32 No. 8 Aug. 8, 1989, pp. 1805-1813 American Chemical Society, Washington, D.C., US G. M. Shutske, et al., "9-Amino-1,2,3,4-Tetrahydroacridin-1-ols; Synthesis and Evaluation as Potential Alzheimer's Disease Therapeutics".
Sugimoto, H. Novel Piperidine Derivatives Synthesis and Anti-Actylcholinesterase Activity of 1-Benzyl-4-[2-(N-benzoylamino)ethyl]piperidine Derivatives, J. Med. Chem. 1990 (33) 1880-1887.

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