Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1988-12-16

1990-05-22

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546153, 546157, 546 79, C07D21504

Patent

active

049279360

ABSTRACT:
The invention concerns a compound formula II ##STR1## or an acid addition salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are the same or different and represent hydrogen, or loweralkyl, cycloalkyl or lower aralkyl, any of which radicals may be substituted by lower alkyl, lower alkoxy or CF.sub.3 or phenyl radicals which may be substituted by lower alkyl or CF.sub.3 or R.sup.2 and R.sup.3 taken together, form a 5, 6 or 7 membered saturated ring R.sup.4 and R.sup.5 may also represent lower alkoxy, or cycloalkoxy, n is 1, 2, or 3 and, if more than one R.sup.4 radical is present the R.sup.4 radicals may be the same or different with the provisos that (1) when R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are all hydrogen, R.sup.6 R.sup.7 are not both hydrogen, (2) when R.sup.1 and R.sup.3 are both phenyl and when R.sup.1 is methyl and R.sup.4 is methyl then R.sup.6 and R.sup.7 are not both methyl, and (3) when R.sup.1 is hydrogen or methyl, R.sup.3 is hydrogen or methyl and R.sup.2, R.sup.4, R.sup.5, and R.sup.6 are all hydrogen then R.sup.7 is other than unsubstituted phenyl.
The compounds are intermediates for other compounds with anti-ulcer activity.

REFERENCES:
patent: 4576949 (1986-03-01), Smith
Epsztajn et al., Roczniki Chemii, 43,807 (1969).
Hahn et al., Roczniki Chemii, 38,989 (1964).
Rosen et al., J. Org. Chem. 42,47 (1977).
Dammertz, et al., Arch. Pharm., 313,826 (1980).
Dammertz et al., Arch. Pharm. 314,302 (1981).
Lodde et al., Arch. Pharm. 312,940 (1979).

Affiliated with

Also associated with

Rating

Quinoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinoline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2135945