Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1991-10-09

1993-03-02

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 81, 546 84, 546103, A61K 3144, C07D47104

Patent

active

051909510

ABSTRACT:
Quinoline derivatives of the formula, ##STR1## wherein > A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior antiacetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.

REFERENCES:
Journal of Medicinal Chemistry, vol. 32, No. 8 Aug. 8, 1989 pp. 1805-1813 American Chemical Society, Wash. DC, US G.M. Shutske, et al., "9-Amino-1,2,3,4-Tetrahydroacridin-1-ols: Synthesis and Evaluation as Potential Alzheimer's Disease Therapeutics".
Sugimoto, H. Novel Piperidine Derivatives Synthesis and Anti-Actylcholinesterase Activity of 1-Benzyl-4[2-(N-benzoylamino)ethyl]piperidine Delivatives J. Med. Chem. 1990 (33) 1880-1887.

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