Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1984-01-18

1989-06-06

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546152, 546 93, 546101, C07D21504

Patent

active

048373290

ABSTRACT:
A process for preparing dihydro compounds of formula I, by rearranging compounds of formula II, e.g. in the presence of acids or noble metal catalysts, is described. The compounds II may be prepared from intermediates of formula III. ##STR1## In these formulae R.sup.1,R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and represent hydrogen, or alkyl, cycloalkyl, aralkyl, or aryl radicals any of which radicals may be substituted, or R.sup.1 and R.sup.2 taken together or R.sup.2 and R.sup.3 taken together, form a 5, 6 or 7 membered ring which may be saturated or unsaturated and substituted or unsubstituted, R.sup.4 and R.sup.5 may also represent alkoxy, or cycloalkoxy, n is 1, 2 or 3 and, if more than one R.sup.4 radical is present the R.sup.4 radicals may be the same or different and R.sup.6 and R.sup.7 represent hydrogen, alkyl, cycloalkyl, or aralkyl radicals.
Most of the compounds I, II and III are novel and are claimed. They are intermediates for anti-ulcer agents.

REFERENCES:
Manske et al., Canadian J. of Research, vol. 20, 1942, pp. 133-151.
Hahn et al., Roczniki Chemii, 38, 989 (1964).
Rosen et al., J. Org. Chem., 42, 47-50 (1977).
Peterson, J. Org. Chem., 33, 780-784 (1968).
Carey et al., J. Org. Chem., 41, 1966-1971 (1976).
Hudrlik et al., J. Am. Chem. Soc., 97, 1464-1468 (1975).

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