Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-06-15
1995-07-18
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544363, A61K 31495, C07D40100
Patent
active
054341558
ABSTRACT:
Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): ##STR1## in which A is ##STR2## (in which R.sub.1, R.sub.2 and R.sub.3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.
REFERENCES:
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5039666 (1991-08-01), Novick, Jr.
patent: 5204348 (1993-04-01), Fukazawa et al.
Journal of Medicinal Chemistry, vol. 35, No. 13, Jun. 26, 1992, pp. 2481-2496, A. Dhainaut, et al., "New Triazine Derivatives as Potent Modulators of Multidrug Resistance".
Fukazawa Nobuyuki
Iwata Daiji
Kawai Yukichi
Otsuka Kengo
Suzuki Tuneji
Mitsui Toatsu Chemicals Incorporated
Tsang Cecilia
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