Quinoline derivative as diagnostic probe for disease with...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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Details

C424S001110, C424S001650, C424S001810, C424S009300, C424S009400

Reexamination Certificate

active

07118730

ABSTRACT:
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.

REFERENCES:
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patent: WO 01/70667 (2001-09-01), None
patent: WO 2004/054978 (2004-07-01), None
International Application No. PCT/JP2003/015269 International Search Report dated Jan. 23, 2004.
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A.K. Sheinkman et al., “Reactions of Cycloammonium Cations. VII. Quinolination of 1-Alkyl-2, 3-Dihydroindoles and 1-Alkyl-1, 2, 3, 4-Tetra Hydroquinolines”,Khimiya Geterotsiklicheskikh Soedinenii, (11), pp. 1515-1521 (1970), Table 3.
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