Quinoline-containing .alpha.-ketoamide cysteine and serine prote

Details Quinoline-containing .alpha.-ketoamide cysteine and serine prote Quinoline-containing .alpha.-ketoamide cysteine and serine prote

1998-10-06

2000-07-04

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514311, 514312, 544128, 546153, 546156, 546169, A61K 3147, A61K 31445, C07D21512, C07D21514, C07D21520

Patent

active

060839449

ABSTRACT:
The present invention is directed to quinoline-containing .alpha.-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.

REFERENCES:
patent: 5034376 (1991-07-01), Hoover et al.
patent: 5162500 (1992-11-01), Takeuchi et al.
patent: 5340825 (1994-08-01), Horwell et al.
patent: 5444042 (1995-08-01), Bartus et al.
patent: 5514694 (1996-05-01), Powers et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5610297 (1997-03-01), Powers
patent: 5614649 (1997-03-01), Iqbal et al.
patent: 5646121 (1997-07-01), Habich et al.
patent: 5650508 (1997-07-01), Powers
patent: 5658885 (1997-08-01), Lee et al.
patent: 5698538 (1997-12-01), Amparo et al.
Amparo, E. C. et al., "Preparation of .alpha.-aminoboronic acid and ester as inhibitors of thrombin", Chemical Abstract, 1996, vol. 125(17), p. 1172, Abstract No. 222432.
Amparo, E.C. et al., "Boronic acid and ester inhibitors of thrombin", Chemical Abstract, 1997, vol. 126(3), p. 594, Abstract No. 31466.
Nagase, H. et al., "Preparation of morphinan derivatives as analgesics and diuretics", Chemical Abstract, 1994, vol. 120(13), p. 1236, Abstract No. 164625.
Tsushima, T. et al., "Preparation of amino acid derivatives as digestive tract hormone antagonists", Chemical Abstract, 1992, vol. 116(25), p. 838, Abstract No. 256040.
Bihovsky et al., "Preparation of benzothiazine-and related heterocyclic group containing amino acids as cysteine and serine protease inhibitors", Chemical Abstract, 1998, vol. 129, WO 98/21186, Abstract No. 28214.
Giardina, G.A.M. et al., Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Indentification of the 4-Quinolinecarboxamide Framework, J. Med. Chem., 1997, 40, 1794-1807.
Harbeson, S.L. et al., "Stereospecific Synthesis of Peptidyl .beta.-Keto Amides as Inhibitors of Calpain", J. Med. Chem., 1994, 37, 2918-2929.
Lehninger, Biochemistry, Second Edition, Worth Publishers, Inc., 1975, 73-75.
Meyer, S.L. et al., "Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system", Biochem. J., 1996, 314, 511-519.

Affiliated with

Also associated with

Rating

Quinoline-containing .alpha.-ketoamide cysteine and serine prote does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinoline-containing .alpha.-ketoamide cysteine and serine prote, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinoline-containing .alpha.-ketoamide cysteine and serine prote will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1486764