Quinoline compounds

Details Quinoline compounds Quinoline compounds

1995-06-07

1997-07-22

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514313, 546153, 546159, C07D21380, A61K 3144

Patent

active

056504152

ABSTRACT:
A method of inhibiting cell proliferation or differentiation by exposing a cell to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. Q is selected from the group consisting of NH and S, n is 0 or 1; and R.sub.1-9 are independently selected from the group consisting of halo, trihalomethyl, alkyl, nitro, hydroxy, alkoxy, sulphoxy, sulphonyl, amide, sulfonamide, carboxamide, amino, and hydrogen. Also provided is a compound of the structure ##STR2##

REFERENCES:
patent: 3470186 (1969-09-01), Hanifin et al.
patent: 4343804 (1982-08-01), Munson, Jr. et al.
patent: 4806550 (1989-02-01), Ife et al.
patent: 4966849 (1990-10-01), Vallee et al.
patent: 5089498 (1992-02-01), Ife et al.
patent: 5143920 (1992-09-01), Ife et al.
patent: 5217999 (1993-06-01), Levitzki et al.
patent: 5302606 (1994-04-01), Spada et al.
patent: 5330992 (1994-07-01), Eissenstat et al.
Mirek, J.; Urbanek, Z. H.;Burzynski, L.;Chojnacka-Wojcik, E.; Wiczynska, B. Synthesis and Pharmacological Properties of sone 7H-[1] Benzothiopyrano-[3,2-c] Quinolin-7-ones. Pol. J. Pharmacol. Pharm. 1983, 35, 139-149 1992.
Marecki, P. E.; Bambury, R. E. Synthesis of 4-Substituted Aminoquinoline-3-carboxylates as Potential Antimicrobial Agents. J. Phar. Sci., 1984, 73 (8), 1141-1143 1984.
Ife, R. J.; Brown, T. H.; Keeling, D. J.; Leach, C. A.; Meeson, M. L.; Parsons, M. E.; Reavill, D. R.; Theobald, C. J.; Wiggall, K. J. Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines. J. Med. Chem., 199 1992.
Savine, L.; Massarelli, P.; Pellerano, C. New Quinoline Derivatives: Synthesis and Evaluation for Antiinflammatory and Analgesic Properties-Note II. II Farmaco, 1993, 48(6), 805-825 1993.
Aaronson, S. A. (1991). Growth factors and cancer. Science 254, 1146-1153.
Arvidsson, A.-K., et al. (1994). Tyr-716 in the platelet-derived growth factor b-receptor kinase insert is involved in GRB2 binding and ras activation. Molecular and Cellular Biology 14, 6715-6726.
Baserga, R. (1995). The insulin-like growth factor I receptor: a key to tumor growth? Cancer Research 55, 249-252.
Bisbee, C. (1995). Scatter factor/hepatocyte growth factor gene deletion leads to death in knockout mice. BioWorld Today 24 Feb. 1995, 2.
Carraway, L. K., et al. (1994). The erbB3 Gene Product Is a Receptor for Heregulin. The Journal of Biological Chemistry 269, 14303-14306.
Carraway, K. L., and Cantley, L. C. (1994). A Neu Acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling. Cell 78, 5-8.
Claesson-Welsh, L. (1994). Signal transduction by the PDGF receptors. Progress in Growth Factor Research 5, 37-54.
Cullen, K. J., Yee, D., and Rosen, N. (1991). Insulinlike Growth Factors in Human Malignancy. Cancer Investigation 9, 443-454.
Dati, C.. Antoniotti, S., Taverna, D., Perroteau, I., and De Bortoli, M. (1990). Inhibition of c-erB-2 oncogene expression by estrogens in human breast cancer cells. Oncogene 5, 1001-1006.
Decker, T., and Lohmann-Matthes, M.-L. (1988). A quick and simple method for quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. of Imm. Methods 15, 61-69.
de Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. (1992). The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255,989-991.
Dougall, W. C., Qian, X., Peterson, N. C., Miller, M. J., Samanta, A., and Greene, M. I. (1994). The neu-oncogene:signal transduction pathways, transformation mechanisms and evolving therapies. Oncogene 9, 2109-2123.
Fendly, B. M. (1990). Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2
eu gene product. Cancer Research 50, 1550-1558.
Ferrara, N., and Henzel, W. J. (1989). Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochemical and Biophysical Research Communications 161,851-858.
Fingl, E., and Woodbury, D. M. (1975). The Pharmacological Basis of Therapeutics Chapter I, 1-46.
Floege, J., Eng, E., Young, B. A., and Johnson, R. J. (1993). Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo. Kidney International 43, S.47-S-54.
Folkman, J. (1971). Tumor Angiogenesis: therapeutic implications. The New England Journal of Medicine v. 285, 18 Nov. 1971, 1182-1186.
Folkman, J. (1990). What is the evidence that tumors are angiogenesis dependent? Journal of the National Cancer Institute 82, 4-6.
Folkman, J., and Shing, Y. (1992). Anglogenesis. The Journal of Biological Chemistry 267, 10931-10934.
Fry, M. J., Panayotou, G., Booker, G. W., and Waterfield, M.D. (1993). New insights into protein-tyrosine kinase receptor signaling complexes. Protein Science 2, 1785-1797.
Giordano, S., Di Renzo, M. F., Olivero, M., Mondino, A., Zhen, Z., Medico, E., and Comoglio, P.M. (1992). The c-met/HGF receptor in human tumours. European Journal of Cancer Prevention 1,45-49.
Gottardis, M. M., Robinson, S. P., and Jordan, C. V. (1988). Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: A model to study the tumoristatic action of tamoxifen. J. Steriod Blochem. 30, 311-314.
Harris, J. R., Lippman, M. E., Veronesi, U., and Willett, W. (1992). Breast Cancer. New England Journal of Medicine 327, 319-328.
Honegger, A. M., et al. (1987). Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell 51, 199-209.
Houck, K. A., et al. (1992). Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. The Journal of Biological Chemistry 267, 26031-26037.
Hu, P., et al. (1992). Interaction of Phosphatidylinositol 3-Kinase-Associated p85 with Epidermal Growth Factor and Platelet-Derive Growth Factor Receptors. Molecular and Cellular Biology 12, 981-990.
Jellinek, D., Green, L. S., and Janjic, N. (1994). Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor. Biochemistry 33, 10450-10456.
Jucker, M., et al. (1994). The Met/Hepatocyte Growth Factor Receptor (HGFR) Gene is Overexpressed in Some Cases of Human Leukemia and Lymphoma. Leukemia Research 18, 7-16.
Kashishian, A., Kazlauskas, A., and Cooper, J. A. (1992). Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. The EMBO J 11, 1373-1382.
Kashishian, A., and Cooper, J. A. (1993). Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase Cg1. Molecular Biology of the Cell 4, 49-57.
Kazlauskas, A., et al. (1993). The 64-kDa protein that associates with the platelet-derived growth factor receptor b subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc. Natl. Acad. Sci. USA 90, 6939-6942.
Kendall, R. L., and Thomas, K. A. (1993). Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl.Acad. Sci. 90, 10705-10709.
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. (1993). Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362, 841-844.
Kinsella, J. L., Grant, D. S., Weeks, B. S., and Kleinman, H. K. (1992). Protein kinase C regulates endothelial cell tube formation on basement membrane matrix, matrigel. Experimental Cell Research 199, 56-62.
Klagsbrun, M., and Soker, S. (1993). VEGF/VPF: the angiogenesis factor found? Current Biology 3, 699-702.
Korzseniewski, C., and Callewaert, D. M. (1983). An enzyme-release assay for natural cytotoxicity. Journal of Immunological Methods 64, 313-320.
Krywicki, and Yee, D. (1992). The insulin-like growth factor family of ligands, receptors, and binding proteins. Breast Cancer Research and Treatment 22, 7-19.
Mariani, M., et al. (1994). Inhibition of angiogenesis by PCE26806, a potent tyrosine kinase inhibitor. Proceedings of the American Associatio

Affiliated with

Also associated with

Rating

Quinoline compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinoline compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinoline compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1560158