Quinoline compound extracted from scolopendra subspinipes, and d

Details Quinoline compound extracted from scolopendra subspinipes, and d Quinoline compound extracted from scolopendra subspinipes, and d

1997-05-30

1998-10-20

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546153, A61K 3147, C07D21524, C07D21520

Patent

active

058246894

ABSTRACT:
The jineol extracted from scolopendra subspinipes is represented as the following formula (I): ##STR1## The jineol is obtained from scolopendra subspinipes by extracting scolopendra subspinipes with a solvent, separating an activating portion from the extracted liquid with an organic solvent, and purifying an anticancerous activating portion from the activating portion by chromatography.
The jineol derivatives prepared from the jineol extracted scolopendra subspinipes are represented as the following formula (II): ##STR2## wherein each R.sub.1 and R.sub.2, independently of each other, is a hydrogen; a lower alkyl group of C.sub.1 to C.sub.6 ; a cycloalkyl group of C.sub.5 to C.sub.7 having a substituting group; an alkyl group of C.sub.1 to C.sub.4 having a phenyl group with one to three substituting groups; a lower alkyl group of C.sub.1 to C.sub.6 having a hydroxy, an alkoxy having C.sub.1 to C.sub.5, or an aryloxy; a lower acyl group of C.sub.1 to C.sub.7 having a hydroxy, an alkoxy having C.sub.1 to C.sub.5, or an aryloxy; a cycloalkylcarbonyl group of C.sub.5 to C.sub.7 with one to three substituting groups; or an acyl group of C.sub.1 to C.sub.4 having a phenyl group with one to three substituting groups.

REFERENCES:
Moon, J Nat Prod, vol. 59, pp. 777-779, Aug. 1996.
J. P. Michael; Quinoline, Quinazoline, and Acridone Alkaloids; pp. 163-172; vol. II, 1994.
James A. Matson & James A. Bush; The Journal of Antibiotics; vol. XLII No. 12; pp. 1763-1767; Sandramycin, A Novel Antitumor Antibiotic Produced by a Nocardioides SP, 1989.
James A. Matson et al.; The Journal of Antibiotics; vol. 46 No. I; pp. 162-166; Sandramycin, A Novel Antitumor Antibiotic Produced by a Nocardioides SP, 1993.

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