Quinoline-carboxylic acid derivatives

Details Quinoline-carboxylic acid derivatives Quinoline-carboxylic acid derivatives

1987-11-27

1989-10-03

Kepplinger, Esther M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546156, C07D40170

Patent

active

048718521

ABSTRACT:
Novel 4-oxoguinoline-3-carboxylic acid derivatives having the formula ##STR1## wherein X.sup.1 represents a halogen or hydrogen atom, X.sup.2 represents a halogen or hydrogen atom, X.sup.3 represents a halogen atom, and R.sup.1, R.sup.2 and R.sup.3 each represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and physiologically acceptable salts thereof, are disclosed. These compounds have excellent antibacterial activity against gram-positive and gram-negative bacteria and beneficial pharmacokinetic properties.

REFERENCES:
patent: 4528287 (1985-07-01), Itoh
patent: 4556658 (1985-12-01), Grohe
patent: 4705788 (1987-11-01), Schriewer et al.
Kyorin Derwent Abstract, C84-089748, (7/84).

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