Quinoline carboxanides and their therapeutic use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514311, 546169, C07D21500, A61K 3147

Patent

active

058045880

ABSTRACT:
The subject invention concerns novel compounds of the general formula (i) ##STR1## that are useful in treating disease states, such as those states associated with proteins that mediate cellular activity. The compounds of the subject invention can be used, for example, to inhibit tumor necrosis factor and/or phosphodiesterase IV, The subject invention also concerns methods for treating disease states using the compounds of the invention.

REFERENCES:
patent: 4147694 (1979-04-01), Erickson
patent: 4186201 (1980-01-01), Erickson
patent: 4238506 (1980-12-01), Stach et al.
Ghosh et al. Chemical Abstracts, vol. 59, No. 5, Abstract 6364 g-h, Sep. 9,1963.
Merchant et al. Chemical Abstracts, vol. 75, No. 10, Abstract 76,564f, Sep.6,1971.

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