Quinoline carboxamides and anti-hypertensive compositions thereo

Details Quinoline carboxamides and anti-hypertensive compositions thereo Quinoline carboxamides and anti-hypertensive compositions thereo

1986-12-15

1989-01-31

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546169, 546157, 546159, 514312, 514313, C07D21514, A61K 3147

Patent

active

048015954

ABSTRACT:
The invention concerns compounds of formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; R.sub.2 represents hydrogen or lower alkyl; A represents an alkylene, oxoalkylene or hydroxyalkylene chain each having 2 to 6 carbon atoms, R.sub.3 and R.sub.4 may be in the same or different rings and independently represent hydrogen, lower alkyl, lower alkoxy, amino or halogen and one of X and Y represents nitrogen the other represents CR.sub.5 wherein R.sub.5 is one of the values for R.sub.3 or R.sub.5 is the bond to the NHCO group; or a pharmaceutically acceptable salt thereof, which compounds possess antihypertensive activity while exhibiting reduced CNS depressant properties. Also disclosed are processes for preparing the compounds and pharmaceutical compositions containing them.

REFERENCES:
patent: 3527761 (1970-09-01), Archibald et al.
patent: 4472403 (1984-09-01), Trijzelaar et al.

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