Quinoline base compound, process for the preparation thereof and

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514285, 546 61, 546 62, C07D22104, C07D491048, C07D49504, A61K 3147

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active

048268500

ABSTRACT:
The present invention provides a quinoline base compound represented by the following general formula (1) of: ##STR1## wherein X is CH.sub.2, O or S. Further provided are the process for the preparation of the aforementioned quinoline base compound and an anticancer agent including the same as a pharmacologically efficacious component.

REFERENCES:
Dzieworski et al., Chem. Abstracts, vol. 59 (1963), entry 11365d.
G. J. Atwell et al., Journal of Medicinal Chemistry, 1972, vol. 15, No. 6, pp. 611-615.
Bruce F. Cain et al., Journal of Medicinal Chemistry, 1974, vol. 17, No. 9, pp. 922-930.
Bruce F. Cain et al., Journal of Medicinal Chemistry, 1975, vol. 18, No. 11, pp. 1110-1117.
David A. Van Echo et al., Cancer Research 39, 3881-3884, Oct. 1979.

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