Quinoline and quinoxaline compounds which inhibit platelet-deriv

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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51425506, 544353, 544354, 544356, 544344, A61K 31498, C07D24136

Patent

active

061599786

ABSTRACT:
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

REFERENCES:
patent: 3272824 (1966-09-01), Ebetino et al.
patent: 4661499 (1987-04-01), Young et al.
patent: 5336518 (1994-08-01), Narayanan et al.
patent: 5409930 (1995-04-01), Spada et al.
patent: 5480883 (1996-01-01), Spada et al.
patent: 5605696 (1997-02-01), Eury et al.
patent: 5637113 (1997-06-01), Tartaglia et al.
patent: 5646153 (1997-07-01), Spada et al.
patent: 5650514 (1997-07-01), Stoltefuss et al.
patent: 5700286 (1997-12-01), Tartaglia et al.
patent: 5700823 (1997-12-01), Hirth et al.
patent: 5760066 (1998-06-01), Tang
patent: 5824049 (1998-10-01), Ragheb et al.
Maguire et al., A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives, J. Med. Chem., 1994, 37, 2129-2137.
Preparation of 3-(N-aryl-and N-heterocyclaminomethyl)indole derivatives having excellent efffect . . . nerve growth factor, Chem. Abstracts, vol. 125, No. 15, p. 1213, col. 2, No. 195667C.
Rice et al., Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats, Am. J. Pathol., 1999, 155(a), pp. 213-221.
Heldin et al., Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor, Physiological Reviews, 1999, 79(4), pp. 1283-1316.
Loriga et al., Quinoxaline Chemistry. Part 4. 2-(R)-Anilinoquinoxalines as Nonclassical Antifolate Agents., II Famaco, 50 (5), 289-301 (1995).
Kim et al., A Selective Synthesis of Isoxazolo [2,3-1]quinoxalines and Pyrrolo[1,2-a]quinoxalines by 1, 3-Dipolar Cycloaddition Reaction, Journal of the Korean Chemical Society, vol. 34, No. 5, 1990, pp. 469-475. Abstract.
Rewcastle et al., Tyrosine Kinase Inhibitors, J. Med. Chem. 1995, 38, 3482-3487.
Newbold et al., The Oxidation of 2-Hydroxyquinoxaline and its Derivatives with Hydrogen Peroxide, J. Chem Soc., 1948 (519-522).
Makino et al., The Syntheses of Novel 2-(2-Quinoxalinyl) Pyridazine-3(2H)-Ones, Heterocycles, vol. 23, No. 10, 1985, pp. 2603-2611.
Burke, Jr., Protein-Tyrosine Kinases: Potential Targets for Anticancer Drug Development, Stem Cells, 1994: 12:1-6.
N-Quinoxalinylanilines, Chemical Abstracts, vol. 103, 1985, 160539f.
Lin et al., Studies on antiarrhythmics, Chemical Abstracts, vol. 96, 1982, 122728w.
Takase et al., Preparation of N-containing heterocyclic compounds as phosphodiesterase inhibitors, Chemical Abstracts, vol. 119, 1993, 203427t.
Hirth et al., , Derwent computer search, 1995, 861279.
Derwent Information Ltd., 1982-64774E JP57102871 Abstract.
Derwent Information Ltd., 1985-168512 Abstract.
Shawyer et al., Inhibition of Platelet-derived Growth Factor-mediated Signal Transduction and Tumor Growth by N-[4-(Trifluoromethyl10-phenyl]5-Methylisoxazole-4-carboxamide, Clinical Cancer Research, vol. 3, 1167-1177, Jul. 1997.
Klutchko et al., 2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones., J. Med. Chem., 1998, 41, 3276-3292.
Sakata et al., , Chem. Abstract, Nippon Noyaku Gakkasishi, 19(1), 61-7, (1985); 109577.
Zellner et al. "Synth.v.Chino.-Derv.";Helv.Chim.Acta49/2,913(1966)/CA64:15882d, Feb. 1966.
Zellner et al, Chemical Abstracts, vol. 64,#15882, Feb. 1966.

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