Quinoline and pyridine anchors for HMG-CoA reductase inhibitors

Details Quinoline and pyridine anchors for HMG-CoA reductase inhibitors Quinoline and pyridine anchors for HMG-CoA reductase inhibitors

1995-10-31

1997-11-25

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 23, 546153, 546154, 546155, 546173, 514311, 514312, 514314, C07F 960, C07F 962, A61K 31675

Patent

active

056913222

ABSTRACT:
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.

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