(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142282, 5142355, 514253, 514312, 514313, 514314, 514826, 514914, 540597, 544 62, 544114, 544121, 544128, 546152, 546153, 546155, 546162, 546168, 546170, 546171, 546172, 546173, 546174, 546175, 546176, 546177, 546178, 546180, 546182, A01N 4342, C07D21504, C07D40100

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052043444

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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S. Biniecki and J. Jakubowski, 98: Chem. Abst. 197936n (1983).
R. Pakula, et al., Sci. Pharm. 53: 139-46 (1985).
A. K. Sheinkman, et al., Chem. 67: 54017n (1967).

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