(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis

Details (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis

1993-12-16

1995-01-10

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546162, 546171, 546176, 546177, 558418, 558442, 564336, 564366, 564372, C07C21100, C07D21512, C07D21516

Patent

active

053808509

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine. RELATED APPLICATION

REFERENCES:
patent: 4629733 (1986-12-01), Muller et al.
patent: 4923881 (1990-05-01), Oku et al.
patent: 4975431 (1990-12-01), Crossley et al.
S. Biniecki & J. Jakubowski, Chem. Abst. 98: 197936n (1983).
R. Pakula, et al., Sci. Pharm. 53: 139-46 (1985).
A. K. Sheinkman, et al., Chem. Abst. 67: 54017n (1967).

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