(Quinolin-2-ylmethoxy)indole/cyclodextrin complex

Details (Quinolin-2-ylmethoxy)indole/cyclodextrin complex (Quinolin-2-ylmethoxy)indole/cyclodextrin complex

1991-11-15

1993-10-19

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514314, 514826, A61K 31715, A61K 3147

Patent

active

052545415

ABSTRACT:
A complex of cyclodextrin and 3-[N-(p-chlorobenzyl)-3-(t-buthylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl] -2,2-dimethylpropanoic acid, sodium salt is more soluble in water than the sodium salt alone. The complex is useful as an anti-asthmatic, anti-allergic, anti-inflammatory, or cytoprotective agent. It is also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

REFERENCES:
patent: 3453259 (1969-07-01), Paramerter et al.
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4727064 (1988-02-01), Pitha
Szejtli, J., Starch, 33, No. 11, 387-390, 1981.
Atwood et al., Inclusion Compounds-Volume 3, Academic Press Inc., Ch. 11, 1984.
Loftsson et al. Inter. J. of Pharm., 67, R5-R7, 1991.
Loftsson, et al., Intl. J. Pharm. 57, 63-72 (1989).
Muller and Albers, J. Pharm. Sci. 80(6), 599-604 (1991).
Rao et al., J. Org. Chem., 56, 1327-1329 (1991).
Pitha et al., Int'l. J. Pharm. 29, 79-38 (1986).
Pitha et al., J. Pharm. Sci. 75(2), 165-167 (1986).
Chem. Abst. 115(19): 207870x, Prasit, EP419049 Mar. 27, 1991 to Merck Frosst Canada.
Martin Physical Pharmacy p. 324, 1983.

Affiliated with

Also associated with

Rating

(Quinolin-2-ylmethoxy)indole/cyclodextrin complex does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Quinolin-2-ylmethoxy)indole/cyclodextrin complex, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Quinolin-2-ylmethoxy)indole/cyclodextrin complex will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1351755