Quinobenzothiazine antineoplastic agents

Details Quinobenzothiazine antineoplastic agents Quinobenzothiazine antineoplastic agents

1994-06-06

1997-04-29

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 14, C07D27936, A61K 3154

Patent

active

056249241

ABSTRACT:
Quinobenzothiazine derivatives of the formula ##STR1## as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R.sup.1 is hydrogen or acarboxy-protecting group, R.sup.2 and R.sup.3 are substitutents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

REFERENCES:
patent: 4529725 (1985-07-01), Chu
patent: 4533663 (1985-08-01), Chu
Chu, Chemical Abstracts, vol. 104, entry 148892 (1985).
Chu, Chemical Abstracts, vol. 104, entry 198598 (1985).
Chu, Chemical Abstracts, vol. 104, entry 5885 (1985).

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