Quinine derivatines

Details Quinine derivatines Quinine derivatines

1980-07-01

1989-04-04

Lone, Werren B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 5002, C07C 5026

Patent

active

048184411

ABSTRACT:
A compound of the general formul: ##STR1## wherein .alpha. .beta. means a saturated bond or a double bond; each R independently of one another is a methyl group or a methoxy group, or two R's taken together represent a group of --CH.dbd.CH--CH.dbd.CH--; n is zero or an integer of 1 through 9; when .alpha. .beta. is a saturated bond, R.sub.2 is a hydrogen atom or hydroxyl group, and when .alpha. .beta. is a double bond, R.sub.2 is a hydrogen atom; when .alpha. .beta. is a double bond or when R.sub.2 is a hydroxyl group, R.sub.1 is a carboxyl group, a group of CH.sub.2.sub.2m OH (wherein m is an integer of 1 through 3) or a group of ##STR2## (wherein m is an integer of 1 through 3); when .alpha. .beta. is a saturated bond and R.sup.2 is a hydrogen atom, R.sub.1 is a hydroxymethyl group or a group of ##STR3## (wherein m is an integer of 1 through 3) has pharmacological actions such as membrane stabilizing activity (e.g. lysosomal membrane stabilizing activity), mitochondrial electron transport activity, hypotensive activity, activity to inhibit cardiac hypertrophy, tracheal muscle relaxant activity, cerebral circulation improving activity and cerebral ischemia preventive activity and is of value in the prophylaxis and treatment of hypertension, cardiac failure, asthma, cerebral apoplexy and other diseases, as a cardiac failure remedy, bronchodilator, cerebral circulation improving agent or the like.

REFERENCES:
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patent: 3849453 (1974-11-01), Morimoto et al.
patent: 3957836 (1976-05-01), Morimoto et al.
patent: 4139545 (1979-02-01), Morimoto et al.
J. Weichet et al., Chemical Abstracts, vol. 65:13771d, 1966.
Creed, David, et al., Journal American Chemical Society, 93:2, Jan. 27, 1971, pp. 502-505, and 508-510.
Imada et al., Biochemistry, vol. 9, No. 14, 1970, 2870-2878.

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