Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-03-19
1995-03-28
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544249, 544250, 544287, 544293, 544289, 544284, 544244, 544279, 544116, 544117, 544105, 544 52, 544 51, 544291, 544285, 544286, 514 80, 5142242, 5142305, 5142342, 5142345, 5142348, 514249, 514258, 514260, 514267, A61K 31505, A61K 3154, C07D23995, C07D23986
Patent
active
054017459
ABSTRACT:
Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebal and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.
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Ries et al, Chemical Abstracts, vol. 119, Entry 8825u (1993).
Greenlee et al, Chemical Abstracts, vol 115, Entry 256214v (1991).
Bagley Scott W.
Chakravarty Prasun K.
Chen Anna
Dhanoa Daljit S.
Fitch Kenneth J.
Camara Valerie J.
Daniel Mark R.
DiPrima Joseph F.
Ford John M.
Merck & Co. , Inc.
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