Quinazolinones as inhibitors of human phosphatidylinositol...

Details Quinazolinones as inhibitors of human phosphatidylinositol... Quinazolinones as inhibitors of human phosphatidylinositol...

2011-04-26

2011-04-26

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S277000, C544S287000

Reexamination Certificate

active

07932260

ABSTRACT:
The invention provides a class of substituted quinazolinone compounds and methods of treating diseases mediated by PI3Kδ activity. The disclosed compounds are useful in treating diseases such as bone-resorption disorders; and cancer, especially hematopoietic cancers, lymphomas, multiple myelomas and leukemia. The compounds are also useful in disrupting or inhibiting cellular processes such as leukocyte function or accumulation, neutrophils function, lymphocyte proliferation, and endogenous immune responses.

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