Quinazolinone T-type calcium channel antagonists

Details Quinazolinone T-type calcium channel antagonists Quinazolinone T-type calcium channel antagonists

2006-03-08

2010-06-29

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S286000

Reexamination Certificate

active

07745452

ABSTRACT:
The present invention is directed to quinazolinone compounds of the formula I:wherein R1, R2, R3, X1, X2X3are defined herein. These compounds are antagonists of T-type calcium channels, and are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

REFERENCES:
patent: 2006/0003985 (2006-01-01), Renger et al.
patent: 2007/0010537 (2007-01-01), Hamamura et al.
patent: 4320347 (1994-12-01), None
patent: 0530994 (1993-03-01), None
patent: WO93/04047 (1993-03-01), None
patent: WO 2004/035000 (2004-04-01), None
Patani, et al. Chem. Rev., 96, 1996, pp. 3147-3176.
S. J. Park et al., “Synthesis and SAR Studies of a Novel Series of T-type Calcium Channel Blockers”, J. Bioorg. Med. Chem, 2006, pp. 1-10.

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