Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-26
1996-09-17
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514259, 544278, 544279, 544284, 544286, C07D23982, C07D23984, A61K 31505, A61K 31435
Patent
active
055568602
ABSTRACT:
This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: ##STR1## typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R.sup.1 represents a hydrogen or chlorine atom; R.sup.2 represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula: ##STR2##
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Hasegawa Hirohiko
Kojima Atsuyuki
Matsui Kazuki
Muraoka Masami
Grumbling Matthew V.
Shah Mukund J.
Sumitomo Pharmaceuticals Co. Ltd.
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