Quinazolinone derivatives as ALDH-2 inhibitors

Details Quinazolinone derivatives as ALDH-2 inhibitors Quinazolinone derivatives as ALDH-2 inhibitors

2011-05-31

2011-05-31

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S287000, C548S131000

Reexamination Certificate

active

07951813

ABSTRACT:
Disclosed are novel quinazolinone derivatives of formula:wherein:R1is optionally substituted phenyl or optionally substituted heteroaryl;R2is 3-hydroxy, 4-hydroxy, 3-NHR4or 4-NHR4, in which R4is hydrogen, —C(O)R5, —C(O)NHR6, or —SO2R6; in whichR5is optionally substituted lower alkyl or optionally substituted lower alkoxy; andR6is optionally substituted lower alkyl;R3is hydrogen, lower alkyl, lower alkoxy, or halo;V is oxygen, sulfur, or —NH—; andW is lower alkylene of 1-3 carbon atoms,which are useful as ALDH-2 inhibitors for treating mammals for various disease states, such as treatment for cocaine dependency and alcohol dependency.

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