Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-09
2011-08-09
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S266300, C544S285000, C544S287000
Reexamination Certificate
active
07994182
ABSTRACT:
The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1stands for either hydrogen or a group of general formula (a); R2stands for a) hydrogen or C1-6alkyl group, if R1is other than hydrogen, and b) if R1is hydrogen, then R2may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.
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Hideg Kálmán
Kálai Tamás
Sümegi Balázs
Pecsi Tudomanyegyetem
Truong Tamthom
Wilson James O
Young & Thompson
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