Quinazolinone copmpounds useful for the prophyloxis and treatmen

Details Quinazolinone copmpounds useful for the prophyloxis and treatmen Quinazolinone copmpounds useful for the prophyloxis and treatmen

1986-05-22

1988-08-09

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544231, 443285, 548485, C07D48710, A61K 31505

Patent

active

047628391

ABSTRACT:
Novel quinazolinone compounds of the formula: ##STR1## wherein R is hydrogen atom or a lower alkyl, R.sup.1 is a lower alkyl, a substituted or unsubstituted phenyl or an aralkyl, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are each hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, a lower alkoxycarbonyl or a lower alkoxycarbonyl-lower alkenyl, or two adjacent groups of R.sup.2,R.sup.3, R.sup.4 and R.sup.5 when taken together form methylenedioxy and the other two are hydrogen atom, and a salt thereof, which are useful for the prophylaxis and treatment of various diabetic complications, and processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.

REFERENCES:
patent: 4117230 (1973-09-01), Sarges
patent: 4248882 (1981-02-01), Sarges
patent: 4273775 (1981-06-01), Sarges
patent: 4282229 (1981-08-01), Sarsas
patent: 4533667 (1985-08-01), Hutchison
patent: 4575507 (1986-03-01), Lipinski
Chemie Berichte, vol. 103, 2394, (1970), by Capuano et al., ("Capuano et al. I").
Chemie Berichte, vol. 110, 3849, (1977), by Capuano et al., ("Capuano et al. II").

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