Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1999-07-29
2000-12-05
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 80, 544244, A01N 5700, A61K 31675, C07F 902
Patent
active
061567396
ABSTRACT:
Phosphate derivatives are disclosed of quinazolinone compounds having structural formula (I) or a pharmaceutically acceptable salt thereof, wherein X' represent hydroxyl, alkyl, alkoxy, or O--Z where Z is a phosphate or phosphate derivative; Y' represents hydrogen, alkyl or an optionally substituted aryl group or optionally substituted aralkyl group; and R' is hydrogen, alkyl, or CH.sub.2 --O--Z where Z is again a phosphate or phosphate derivative; subject to the proviso that if neither X' nor R' contains Z, Y' is an aryl or aralkyl group having an O--Z substituent therein with Z once again being a phosphate or phosphate derivative as hereinabove defined. These compounds are useful as prodrugs for providing active PARP inhibiting substances for medical use in conjunction with a cytotoxic drug or radiotherapy in order to increase the effectiveness of the latter, especially in connection with antitumor treatment. ##STR1##
REFERENCES:
patent: 5798344 (1998-08-01), Kuroki et al.
Calvert Alan Hilary
Curtin Jane Nicola
Golding Bernard Thomas
Griffin Roger John
Newell David Richard
Newcastle University Ventures Limited
Schroeder Ben
Shah Mukund J.
LandOfFree
Quinazolinone compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinazolinone compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazolinone compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-961857