Quinazolinone and isoquinolinone acetamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S575000, C544S289000, C546S141000

Reexamination Certificate

active

07820649

ABSTRACT:
Disclosed herein are quinazolinone or isoquinolinone derivatives of formula I,or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.

REFERENCES:
patent: 4438121 (1984-03-01), Obitz
patent: 6730695 (2004-05-01), Roux
patent: 7202267 (2007-04-01), Aulombard et al.
patent: WO 01/55130 (2001-08-01), None
patent: WO 2004/009585 (2004-01-01), None
patent: WO 2006/095014 (2006-09-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 and 365.
Bernardini et al., “In vivo and in vitro Effects of Arginine-Vasopressin Receptor Antagonists on the Hypothalamic-Pituitary-Adrenal Axis in the Rat,”Neuroendocrinology 60(1994) 503-508.
De Bold et al., “Arginine Vasopressin Potentiates Adrenocorticotropin Release Induced by Ovine Corticotropin-releasing Factor, ”J. Clin. Invest. 73(1984) 533-538.
De Goeij et al., “Repeated Stress-Induced Activation of Corticotropin-Releasing Factor Neurons Enhances vasopressin Stores and Colocalization with Corticotrophin-Releasing Factor in the Median Eminence of Rats,”Neuroendocrinology 53(1991) 150-159.
Freidinger et al., “Small Molecule Ligands for Oxytocin and Vasopressin Receptors,”Medicinal Research Reviews 17(1997) 1-16.
Holsboer et al., “Human Corticotropin-Releasing Hormone in Depression-Correlation with Thyrotropin Secretion following Thyrotropin-Releasing Hormone,”Biol. Psychiatry 21(1986) 601-611.
Moss et al., “Catalytic cleavage of active phosphate and ester substrates by iodoso- and iodoxybenzoates,” J. Am. Chem. Soc. 106 (1984) 2651-2655.
Plotsky et al., “Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats,”Mol. Brain Res. 18(1993) 195-200.
Rivier et al., “Modulation of stress-induced ACTH release by corticotrophin-releasing factor, catecholamines and vasopressin,”Nature 305(1983) 325-327.
Scott et al., “Vasopressin and the Regulation of Hypothalamic-Pituitary-Adrenal Axis Function: Implications for the Pathophysiology of Depression,”Life Sciences 62(1998) 1985-1988.
Sugimoto et al., “Molecular Cloning and Functional Expression of a cDNA Encoding the Human V1bVasopressin Recepto,”J. Biol. Chem. 269(1994) 27088-27092.
International Search Report and Written Opinion dated Jul. 4, 2006 for related International Application No. PCT/EP2006/060612.
Balawant et al., “Synthesis of Pratorimine,”Journal of Natural Product49:445-448 (1986).
Borcherding et al., “Carbocyclic Nucleosides as Inhibitors of Human Tumor Necrosis Factor-α Production: Effects of the Stereoisomers of (3-Hydroxycyclopentyl)adenines,”J. Med. Chem.39:2615-2620 (1996).
Jordan, V. Craig, “Tamoxifen: a most unlikely pioneering medicine”,Nature Reviews: Drug Discovery2(14):205 (2003).
Venuti et al., “Inhibitors of Cyclic AMP Phosphodiesterase. 3. Synthesis and Biological Evaluation of Pyrido and Imidazolyl Analogues of 1,2,3,5-Tetrahydro-2-oxoimidazo2[,1-b]lquinazoline,”J. Med. Chem.31:2136-2145 (1988).
Vippagunta et al., “Crystalline Solids”,Advanced Drug Delivery Reviews, 48(1):3-26 (May 16, 2001).
International Search Report and Written Opinion dated Oct. 3, 2008 for corresponding International Application No. PCT/US07/78022.
International Search Report and Written Opinion dated Oct. 7, 2008 for related International Application No. PCT/US07/77999.
West, Anthony R., “Chapter 10. Solid Solutions”,Solid State Chemistry and Its Applications, pp. 358 and 365; John Wiley & Sons, Pub., New York (1988).

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