Quinazolines and phthalazines having adenosine uptake inhibitor

Details Quinazolines and phthalazines having adenosine uptake inhibitor Quinazolines and phthalazines having adenosine uptake inhibitor

1995-05-22

1997-07-15

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544237, 544250, 544212, 544284, 544234, 514259, 514245, C07D40104, A61K 3150, A61K 31505, A61K 31445

Patent

active

056483538

ABSTRACT:
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),

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Nomoto, Y. et al., Chem. Pharm. Bull., vol. 38, No. 6 (1990) 1591-95. Month of publication not provided.
Young, M.A. et al. Am. J. Physiol., 261, H1570-H1577 (1991). Month of publication not provided.
Dorion, M. et al. J. Cardiovasc. Pharmacol. 19, 69-77 (1992). Month of publication not provided.
Remington's Pharm. Sci., Phila. Coll. Pharm., Phila. (1992) 1286-1292. Month of publication not provided.

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