Quinazoline thymidylate synthase inhibitors

Details Quinazoline thymidylate synthase inhibitors Quinazoline thymidylate synthase inhibitors

1993-03-09

1999-09-21

Grumbling, Mathew

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544284, A61K 31505, C07D40312

Patent

active

059554630

ABSTRACT:
The invention relates to quinazoline derivatives or pharceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them.
The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy;

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