Quinazoline derivatives, their preparation, their use, and...

Details Quinazoline derivatives, their preparation, their use, and... Quinazoline derivatives, their preparation, their use, and...

2007-06-21

2010-06-22

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S250000

Reexamination Certificate

active

07741333

ABSTRACT:
The present invention relates to a quinazoline derivative having the general formula (A):in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).

REFERENCES:
patent: 2003/0186987 (2003-10-01), Bridges et al.
patent: WO 96/19970 (1995-07-01), None
Rewcastle, et al., Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor, J. Med. Chem. 39, 918-928 (1996).
Gordon W. Rewcastle, et al.; “Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused trycyclic quinazoline . . . ”; Journal of Medicinal Chemistry; 1996; pp. 918-928; vol. 39(4).
H.D. Hollis Showalter, et al.; “Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b] . . . ”; Journal of Medicinal Chemistry; 1999; pp. 5464-5474; vol. 42(26).

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