Quinazoline derivatives as kinase inhibitors

Details Quinazoline derivatives as kinase inhibitors Quinazoline derivatives as kinase inhibitors

2006-01-03

2006-01-03

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S234500, C514S235200, C544S118000, C544S284000

Reexamination Certificate

active

06982266

ABSTRACT:
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

REFERENCES:
patent: 6169088 (2001-01-01), Matsuno et al.
patent: 6207667 (2001-03-01), Matsuno et al.
patent: 6423716 (2002-07-01), Matsuno et al.
patent: 6472391 (2002-10-01), Matsuno et al.
patent: 6750218 (2004-06-01), Matsuno et al.
patent: 2002/0068734 (2002-06-01), Matsuno et al.
patent: 2003/0100573 (2003-05-01), Wang et al.
patent: 2005/0070560 (2005-03-01), Himmelsbach et al.
patent: 0 882 717 (1998-12-01), None
patent: 1 067 123 (2001-01-01), None
patent: 99-51582 (1999-10-01), None
patent: WO 02/16360 (2002-02-01), None
patent: WO 02/16361 (2002-02-01), None
patent: WO 02/16362 (2002-02-01), None
patent: WO 02/072578 (2002-09-01), None
Agrawal, Vijal et al.: “Antiparasitic agents. Part VI: Synthesis of 7-chloro-4-(4-substituted-phenylanino)- and 7-chloro-4-(4-substituted-piperazin-1-yl)quinolines as potential antiparasitic agents” Indian J. Chem., Sect. B (1987), 26(B)6, pp. 550-555.

Affiliated with

Also associated with

Rating

Quinazoline derivatives as kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinazoline derivatives as kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazoline derivatives as kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3604145