Quinazoline derivatives as angiogenesis inhibitors

Details Quinazoline derivatives as angiogenesis inhibitors Quinazoline derivatives as angiogenesis inhibitors

2011-08-02

2011-08-02

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S284000, C544S287000

Reexamination Certificate

active

07989460

ABSTRACT:
The present invention relates to compounds of the formula I:wherein: ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which moiety may be saturated or unsaturated, which may be aromatic or non-aromatic, and which optionally may contain 1-3 heteroatoms selected independently from O, N and S; is —O— —NH— or —S—; is 0, 1, 2, 3, 4 or 5; is 0, 1, 2 or 3; and R2and R1are as defined herein; and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals; processes for the preparation of such compounds; pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

REFERENCES:
patent: 7074800 (2006-07-01), Stokes et al.
patent: 7268230 (2007-09-01), Hennequin
patent: 2006/0004017 (2006-01-01), Stokes et al.
patent: 2008/0027069 (2008-01-01), Hennequin
patent: 2009/0156821 (2009-06-01), Hennequin
patent: WO 00/47212 (2000-08-01), None
patent: WO 03/064413 (2003-08-01), None

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