Quinazoline derivatives as acetylcholinesterase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540543, 540579, 544245, 544246, 544252, C07D48704, A61K 3155

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active

054865123

ABSTRACT:
A method of treating cognitive deficiencies is described by administering a quinazoline derivative of the general formula ##STR1## wherein A represents ##STR2## in which n is 1-10, P is a bond or (CH.sub.2).sub.m in which m is 0-10, and M is .dbd.O, .dbd.S, .dbd.NR, .dbd.CRR', ##STR3## novel compounds of the above are also described as well as methods of manufacture and pharmaceutical compositions.

REFERENCES:
patent: 2992221 (1961-07-01), Petersen
patent: 3271396 (1966-09-01), Bernstein et al.
patent: 3745216 (1973-07-01), Jen et al.
patent: 3932407 (1976-01-01), Beverung, Jr. et al.
patent: 4220771 (1980-09-01), Hermecz et al.
patent: 4395554 (1983-07-01), Hermecz et al.
patent: 4428952 (1984-01-01), Dorin et al.
patent: 4670434 (1987-06-01), Venuti
patent: 4690925 (1987-09-01), Fried et al.
patent: 4837239 (1989-06-01), Benjamin et al.
Abstract SU-605-614 (1978) As UZB Chem Growing A. Karimov, et al., "I. Synthesis of Methoxy-And Hydroxy-Substituted . . . ", translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 498-504, 1982.
A. Karimov, et al., "II. Synthesis of 5-Methoxy-. . . " Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 396-397, 1983.
G. Devi, et al., "Potential CNS & CVS Agents: Syntheses Based on Vasicinone", Indian Journal of Chemistry, vol. 14B, May 1976, pp. 354-356.
A. D'yakonov, et al., "III. Pentamethylenequinazolones", Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 465-469, 1986.
F. Kuffner, et al., "Uber die Konstitution eines Nebenalkaloides aus Adhatoda vasica Nees", Monatshefte fur Chemie, Bd. 91/6, pp. 1153-1161, (1960).
Kh. Shakhidoyatov, et al., "Condensation of Acetanilides with N-Methylolpyrrolidone", translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 834-837.
Abstract J5 3044-597 (1978) Daiichi Pharm KK.
Abstract J5 2077-093 (1977) Chugai Pharmaceutical KK.
Abstract J4 9076-899 (1974) Nippon Chemipha Co. Ltd.
Research Disclosure 183003, Crenshaw, R., et al., "Process for the preparation of cardiovascular agents", 55676B.
PCT International Search Report, International Application No. PCT/US 92/05864 filed Jul. 22, 1992.
Langluis et al., J. Het. Chem., 20, pp. 393-398 (1983).
Burger, Medicinal Chemistry, 3rd ed (1970), Part I, pp. 72-75.
Malhorta et al., Chem. Abstract 112:7445p (1989).
Hermecz et al., Chem. Abstract 107:198290p (1987).
Brown et al., Chem. Abstract 84:43969z (1975).
Irisbaev et al., Chem. Abstract 84:4894b (1975).
Shalchildoyatov et al., Chem. Abst. 86:106517q (1976).
Ishikawa et al., Chem. Abst. 89:109566c (1976).
Drug Evaluations, 6th ed (1986), Amer. Med Assn., pp. 160-162.
Cecil Textbook of Medicine, 19th ed (1992), Wyngaarden, M.D. editor, pp. 2075-2079.

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