Quinazoline derivatives and their use in the treatment of...

Details Quinazoline derivatives and their use in the treatment of... Quinazoline derivatives and their use in the treatment of...

2004-04-27

2010-02-09

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S293000

Reexamination Certificate

active

07659279

ABSTRACT:
The invention concerns quinazoline derivatives of the formula: (I); wherein X1, Q1, Z, R1, R2, Y, a and m are as defined in the description, which are erbB tyrosine kinase inhibitors, particularly EGFR tyrosine kinase inhibitors. Also claimed are processes for their preparation; pharmaceutical compositions containing them; and their use as therapeutic agents in the treatment of erbB tyrosine kinase mediated diseases such as cancer.

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