Quinazoline derivatives and pharmaceutical composition thereof

Details Quinazoline derivatives and pharmaceutical composition thereof Quinazoline derivatives and pharmaceutical composition thereof

1980-10-21

1986-08-19

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514218, 544291, A61K 31505, C07D40304

Patent

active

046070346

ABSTRACT:
There are presented novel quinazoline derivatives, namely 2-(4-substituted-carbamoyl-piperazin-1-yl)quinazoline derivatives, 2-(4-substituted-carbamoyl-homopiperazin-1-yl)quinazoline derivatives, 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives and 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives, having excellent antihypertensive activities.

REFERENCES:
patent: 3635979 (1972-01-01), Hess
patent: 4001237 (1977-01-01), Partyka et al.
patent: 4062844 (1977-12-01), Hammen
patent: 4243666 (1981-01-01), Campbell et al.
patent: 4287341 (1981-09-01), Hess et al.
Sekiya et al., Pyrimidine derivatives 1. Eur. J. Med. Chem.--Chimica Therapeutica, Jul.-Aug. 1980-15, No. 4, pp. 317-322.

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