Quinazoline derivatives and pharmaceutical applications thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S090000, C544S105000, C546S158000

Reexamination Certificate

active

11073654

ABSTRACT:
A quianazoline derivative having the formula (1):or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase and useful as a medicament, and a pharmaceutical composition containing the same as an essential ingredient.

REFERENCES:
patent: 5304560 (1994-04-01), Shimazaki et al.
patent: 5814631 (1998-09-01), Fukami et al.
patent: 0 795 548 (1997-09-01), None
patent: 3243/91 (1992-05-01), None
patent: 05 169832 (1993-07-01), None
patent: 97/45400 (1997-12-01), None
Y. Liao et al., “The chymase-angiotensin system in humans: Biochemistry, molecular biology and potential role in cardiovascular diseases”, Canadian Journal of Cardiology, 1995, pp. 13F-19F, vol. 11 Suppl. F Pulsus Group Inc., Canada.
S. Niwata et al., “Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione Derivatives as Novel Nonpeptide Inhibitors of Human Heart Chymase”, Journal of Medicinal Chemistry, 1997, pp. 2156-2163, vol. 40, No. 14, American Chemical Society Publications, Washington, DC.
Jun-Ichi Sadoshima et al., “Molecular Characterization of Angiotensin II—Induced Hypertrophy of Cardiac Myocytes and Hyperplasia of Cardiac Fibroblasts”, Am. J. Physiol. Heart Circ. Physiol, Sep. 1993, pp. 413-423, vol. 13, No. 3, American Physiological Society, Bethesda, MD.
Eduardo Bacells et al., “Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations”, Am. J. Physiol. Heart Circ. Physiol., 1997, pp. H1769-H1774, vol. 273, American Physiological Society, Bethesda, MD.
Bertram Pitt et al., “Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)”, The Lancet, 1997, pp. 747-752, vol. 349, Elsevier, NY.
Hiroyuki Yamagishi et al, “Contribution of Cardiac Renin-Angiotensin System to Ventricular Remodelling in Myocardial-Infarcted Rats”, J. Mol. Cell Cardiol., 1993, pp. 1369-1380, vol. 25, Elsevier, NY.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Quinazoline derivatives and pharmaceutical applications thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinazoline derivatives and pharmaceutical applications thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazoline derivatives and pharmaceutical applications thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3755499

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.