Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-15
2005-03-15
Berch, Mark L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S285000, C544S105000, C564S042000
Reexamination Certificate
active
06867214
ABSTRACT:
A quinazoline derivative having formula (1) and a pharmaceutically acceptable salt thereof:wherein the ring A represents an aryl group,which derivative has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase, and a pharmaceutical composition containing the same as an essential ingredient. These compounds are useful for treatment of allergic diseases, rheumatic diseases, and cardiac and circulatory system diseases which are due to the abnormal exacerbation of Angiotensin II production.
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S. Niwata et al., “Substituted 3-(Phenylsulfonyl)-1-phenylimidazolidine-2,4-dione Derivatives as Novel Nonpeptide Inhibitors of Human Heart Chymase”, Journal of Medicinal Chemistry, vol. 40, No. 14, 1997, pp. 2156-2163.
Fukami Harukazu
Imajo Seiichi
Ito Akiko
Berch Mark L
Burns Doane Swecker & Mathis L.L.P.
Daiichi Suntory Pharma Co., Ltd.
Habte Kahsay
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