Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-15
1999-02-02
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514260, 544283, A61K 31505, C07D23972
Patent
active
058665803
ABSTRACT:
The present invention discloses compounds, and pharmaceutically acceptable salts thereof, having the following formula (5): ##STR1## wherein X and Y are the same or different and are either OH or NH.sub.2 ; wherein A is either nitrogen, CH or sulfur, and B equals CH when A is sulfur, CH or nitrogen, or B equals nitrogen when A equals CH, or B equals sulfur when A equals CH; wherein R.sub.3 is hydrogen; wherein R.sub.4 is either hydrogen or a lower alkyl group, and is zero when A is sulfur; wherein R.sub.1 is either hydrogen, a nitroso group, a formyl group, or a lower alkyl group, and is zero when B is sulfur; and wherein R.sub.2 is a lower alkyl group, a substituted or unsubstituted aryl, diaryl, triaryl, alkylaryl, alkyldiaryl, or alkyltriaryl group, or an alicyclic hydrocarbon group. Substituents on the R.sub.2 groups can include a lower alkyl group, an alkoxy, a substituted alkoxyaryloxy group and a halogen. Methods of using these compounds for therapeutically and prophylactically treating an illness caused by P. carinii and T. gondii are also disclosed.
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Duguesne University of the Holy Ghost
Meyers Diane R.
Shah Mukund J.
Silverman Arnold B.
Sripada Pavanaram K.
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