Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-12-10
1996-12-03
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514249, 514259, 514267, 544119, 544250, 544284, 544293, A61K 31505, C07D23995, C07D23978, C07D23984
Patent
active
055808700
ABSTRACT:
The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, ureido, hydroxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; and Q is a 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur, or Q is a 9- or 10-membered bicyclic aryl moiety which heterocyclic or aryl moiety may optionally bear one or two substituents selected from halogeno, hydroxy, oxo, amino, nitro, carbamoyl, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di-[(1-4C)alkyl]amino and (2-4C)alkanoylamino; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
REFERENCES:
patent: 3470182 (1969-09-01), Hardtmann et al.
Hiroshi; "On The Animation Of Azaheterocycles" Chemical Abstracts, 1983, vol. 98, p. 577, 143376M.
Burke, Jr; "Protein-Tyrosine Kinase Inhibitors", Drugs Of The Future, 1992, vol. 17, No. 2, pp. 119-131.
Mingli; "Synthesis and Antimalarial Activity of 2-Dialkylaminomethyl-4-(Heterocyclic Amino)-5, 6, 7, 8-Tetrahydronophthol Derivatives", Chemical Abstracts 1985, vol. 103 pp. 597-598, 87753q.
Barker Andrew J.
Brown Dearg S.
Grumbling Matthew V.
Shah Mukund J.
Zeneca Limited
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