Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-02-13
1988-06-07
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544250, 544283, 544285, 544291, 544293, A61K 31501, C07D23984, C07D49152
Patent
active
047497050
ABSTRACT:
New quinazoline derivatives are disclosed, as represented by the following formula: ##STR1## wherein A is hydrogen atom or lower alkyloxy group; R.sub.4 is hydrogen atom, a lower alkyl, lower alkyloxy or a halogen atom group. Y is hydrogen atom, lower alkyloxy, sulfamoyl or Y and R.sub.4, taken together, are joined to form --O--CH.sub.2 --CH.sub.2 --O--; Z is a 4-oxopiperidino, 4-thioxopiperidino, 4-oximepiperidino, 4-O-loweralkyl-oxime-piperidino, 4-O-(3-lower alkyl-2-hydroxypropyl)-oxime-piperidino, 4-O-(3-lower alkylamino-2-hydroxypropyl)-oxime-piperidino or 4-O-(3-N'-lower alkyl, N'-benzylamino-2-hydroxypropyl)-oxime-piperidino group. These compounds are useful as anti-hypertensive agents.
REFERENCES:
patent: 3574212 (1971-04-01), Hess
patent: 4539323 (1985-09-01), Mentrup et al.
Ichikawa Yumiko
Kawai Tomoyuki
Tomiyama Tsuyoshi
Burns Robert E.
Hollrah Glennon H.
Kotobuki Seiyaku Co. Ltd.
Lobato Emmanuel J.
Turnipseed James H.
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