Quinazoline compounds

Details Quinazoline compounds Quinazoline compounds

2007-01-09

2007-01-09

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S258100, C544S242000, C544S253000

Reexamination Certificate

active

10240658

ABSTRACT:
The invention concerns quinazoline derivatives of Formula (I)wherein ring A is phenyl or a 5-or 6-membered heterocyclic ring which may be saturated, partially saturated or unsaturated and may be aromatic or non-aromatic and which contains 1, 2 or 3 ring heteroatoms selected from O, N and S; Z is —O—, —NH— or —S—; and X1, R1, R2, R3, m and R4have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in producing an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, and in the treatment of disease states such as cancer, rheumatoid arthritis and psorlasis.

REFERENCES:
patent: 3266990 (1966-08-01), Lutz et al.
patent: 3376195 (1968-04-01), Allais et al.
patent: 4343940 (1982-08-01), Kreighbaum et al.
patent: 4421920 (1983-12-01), Baudouin et al.
patent: 5373011 (1994-12-01), Haley
patent: 5409930 (1995-04-01), Spada et al.
patent: 5411963 (1995-05-01), Dreikorn et al.
patent: 5457105 (1995-10-01), Barker
patent: 5475001 (1995-12-01), Barker
patent: 5480883 (1996-01-01), Spada et al.
patent: 5569658 (1996-10-01), Barker
patent: 5571815 (1996-11-01), Schaper et al.
patent: 5580870 (1996-12-01), Barker et al.
patent: 5616582 (1997-04-01), Barker
patent: 5646153 (1997-07-01), Spada et al.
patent: 5650415 (1997-07-01), Tang et al.
patent: 5656643 (1997-08-01), Spada et al.
patent: 5710158 (1998-01-01), Myers et al.
patent: 5712395 (1998-01-01), App et al.
patent: 5714493 (1998-02-01), Myers et al.
patent: 5721237 (1998-02-01), Myers et al.
patent: 5736534 (1998-04-01), Arnold
patent: 5747498 (1998-05-01), Schnur et al.
patent: 5770599 (1998-06-01), Gibson
patent: 5770603 (1998-06-01), Gibson
patent: 5792771 (1998-08-01), App et al.
patent: 5814630 (1998-09-01), Barker et al.
patent: 5821246 (1998-10-01), Brown et al.
patent: 5866572 (1999-02-01), Barker et al.
patent: 5929080 (1999-07-01), Frost
patent: 5932574 (1999-08-01), Barker
patent: 5942514 (1999-08-01), Barker
patent: 5952333 (1999-09-01), Barker
patent: 5955464 (1999-09-01), Barker
patent: 5962458 (1999-10-01), Lohmann et al.
patent: 6002008 (1999-12-01), Wissner et al.
patent: 6015814 (2000-01-01), Barker
patent: 6057320 (2000-05-01), Spada et al.
patent: 6071921 (2000-06-01), Lohmann et al.
patent: 6184225 (2001-02-01), Thomas et al.
patent: 6258951 (2001-07-01), Lohmann et al.
patent: 6265411 (2001-07-01), Thomas et al.
patent: 6291455 (2001-09-01), Thomas et al.
patent: 6294532 (2001-09-01), Thomas et al.
patent: 6362336 (2002-03-01), Lohmann et al.
patent: 6414148 (2002-07-01), Thomas et al.
patent: 6514971 (2003-02-01), Thomas et al.
patent: 6673803 (2004-01-01), Thomas et al.
patent: 6809097 (2004-10-01), Thomas et al.
patent: 6887874 (2005-05-01), Hennequin
patent: 6897210 (2005-05-01), Thomas et al.
patent: 2003/0144298 (2003-07-01), Curwen et al.
patent: 2003/0199491 (2003-10-01), Hennequin
patent: 2003/0199513 (2003-10-01), Thomas et al.
patent: 2003/0207878 (2003-11-01), Hennequin
patent: 2003/0225111 (2003-12-01), Hennequin et al.
patent: 2005/0043395 (2005-02-01), Wedge
patent: 2005/0085465 (2005-04-01), Hennequin
patent: 2005/0222183 (2005-10-01), Wedge
patent: 2005/0239777 (2005-10-01), Thomas et al.
patent: 02213558 (1972-10-01), None
patent: 19614718 (1997-10-01), None
patent: 199 11 509 (2000-09-01), None
patent: 19911509 (2000-09-01), None
patent: 0 326 307 (1989-08-01), None
patent: 0 326 330 (1989-08-01), None
patent: 0 520 722 (1992-12-01), None
patent: 0 566 226 (1993-10-01), None
patent: 0 602 851 (1994-06-01), None
patent: 0 635 498 (1995-01-01), None
patent: 0 635 507 (1995-01-01), None
patent: 0 743 308 (1996-11-01), None
patent: 0 787 722 (1997-08-01), None
patent: 0 837 063 (1998-04-01), None
patent: 2077455 (1969-09-01), None
patent: 2 033 894 (1980-05-01), None
patent: 2 160 201 (1985-12-01), None
patent: 54-2327 (1979-09-01), None
patent: WO 87/04321 (1987-07-01), None
patent: WO 92/14716 (1992-09-01), None
patent: WO 92/16527 (1992-10-01), None
patent: WO 92/20642 (1992-11-01), None
patent: WO 93/03030 (1993-02-01), None
patent: WO 93/13097 (1993-07-01), None
patent: WO 95/15758 (1995-06-01), None
patent: WO 95/19169 (1995-07-01), None
patent: WO 95/21613 (1995-08-01), None
patent: WO 95/23141 (1995-08-01), None
patent: WO 95/24190 (1995-09-01), None
patent: WO 96/09294 (1996-03-01), None
patent: WO 96/15118 (1996-05-01), None
patent: WO 96/16960 (1996-06-01), None
patent: WO 96/29331 (1996-09-01), None
patent: WO 96/30347 (1996-10-01), None
patent: WO 96/30370 (1996-10-01), None
patent: WO 96/33977 (1996-10-01), None
patent: WO 96/33978 (1996-10-01), None
patent: WO 96/33979 (1996-10-01), None
patent: WO 96/33980 (1996-10-01), None
patent: WO 96/33981 (1996-10-01), None
patent: WO 96/39145 (1996-12-01), None
patent: WO 96/40648 (1996-12-01), None
patent: WO 96/40673 (1996-12-01), None
patent: WO 97/02266 (1997-01-01), None
patent: WO 97/03069 (1997-01-01), None
patent: WO 97/17329 (1997-05-01), None
patent: 97/22596 (1997-06-01), None
patent: WO 97/22596 (1997-06-01), None
patent: 97/30035 (1997-08-01), None
patent: WO 97/28161 (1997-08-01), None
patent: WO 97/30034 (1997-08-01), None
patent: WO 97/30035 (1997-08-01), None
patent: WO 97/30044 (1997-08-01), None
patent: 97/32856 (1997-09-01), None
patent: WO 97/32856 (1997-09-01), None
patent: WO 97/34876 (1997-09-01), None
patent: 97/38983 (1997-10-01), None
patent: WO 97/37999 (1997-10-01), None
patent: WO 97/38983 (1997-10-01), None
patent: WO 97/38994 (1997-10-01), None
patent: WO 97/42187 (1997-11-01), None
patent: WO 97/49689 (1997-12-01), None
patent: WO 98/02434 (1998-01-01), None
patent: WO 98/10767 (1998-03-01), None
patent: 98/13354 (1998-04-01), None
patent: WO 98/13350 (1998-04-01), None
patent: WO 98/13354 (1998-04-01), None
patent: WO 98/14431 (1998-04-01), None
patent: WO 98/23613 (1998-06-01), None
patent: WO 98/35958 (1998-08-01), None
patent: WO 98/43960 (1998-10-01), None
patent: WO 98/50038 (1998-11-01), None
patent: WO 99/06378 (1999-02-01), None
patent: WO 99/06396 (1999-02-01), None
patent: WO 99/09016 (1999-02-01), None
patent: WO 99/09024 (1999-02-01), None
patent: WO 99/10349 (1999-03-01), None
patent: WO 00/12497 (2000-03-01), None
patent: WO 00/21955 (2000-04-01), None
patent: WO 00/47212 (2000-08-01), None
patent: WO 01/32651 (2001-05-01), None
patent: WO 01/66099 (2001-09-01), None
patent: WO 01/74360 (2001-10-01), None
patent: WO 02/12226 (2002-02-01), None
patent: WO 02/12227 (2002-02-01), None
patent: WO 02/12228 (2002-02-01), None
patent: WO 03/039551 (2003-05-01), None
patent: WO 03/064413 (2003-08-01), None
patent: WO 04/014383 (2004-02-01), None
patent: WO 04/014426 (2004-02-01), None
patent: WO 04/032937 (2004-04-01), None
patent: WO 04/071397 (2004-08-01), None
Hennequin et al., “Design and Structure . . . ”, J. Med. Chem 1999, 42, 5369-5389.
US RE36265, 08/1999, Spada et al. (withdrawn).
Arya et al., Nitroimidazoles: Part XVI—Some 1-Methyl-4-nitro-5-substituted Imidazoles, Indian Journal of Chemistry, vol. 21B, Dec. 1982, pp. 1115-1117.
Bridges, “The current status of tyrosine kinase inhibitors . . . ,” Exp.Opin.Ther.Patents (1995), 5(12): 1245-1257, Editorial, Oncologic, Endocrine & Metabolic, 1995 Ashley Publications Ltd ISSN 1354-3776.
Bridges, et al., “Enantioselective Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase by 4-(a-Phenethylamino)quinazolines,” Bioorganic & Medicinal Chemistry, vol. 3, No. 12, pp. 1651-1656, 1995.
Connolly, et al., “Human Vascular Permeability Factor,” J.Bio.Chem., vol. 264, No. 33, Nov. 1989, pp. 20017-20024.
Cullinan-Bove, et al., “Vascular Endothelial Growth Factor/Vascular Permeability Factor Expression in the Rat Uterus . . . ,” Endocrinology, vol. 133, No. 2, 1993, pp. 829-837.
Fan, et al., “Controlling the Vasculature: Angiogenesis, Anti-Angiogenesis . . . ,” TiPS Review, vol. 16, Feb. 1995, pp. 57-65.
Folkman, “Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease,”

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